New clinical trial seeks participants

Scientific Research Banner

One of the Lewy Body Society’s main aims is to support research into Lewy body dementia, to help improve diagnosis and treatment of the disease in future.

We are delighted that a new trial will be starting in 2019 in a number of different hospitals and research centres across the UK.

The trial is open to people with a diagnosis of dementia with Lewy bodies who are under the care of the hospitals listed below. If you, or someone you know, would be interested in participating in the trial, please tell your consultant. We hope that the trial will be opened up to patients in other areas soon and we will update this page when that happens.

We would also like to encourage everyone to register with Join Dementia Research, so that you can be notified about suitable trials in future.

What is the trial testing?

The trial is a 12 week randomised controlled trial of a medication called E2027. E2027 is made by EISAI, the same company that invented Donepezil. E2027 works by blocking an enzyme in the brain called Phosphodiesterase 9. Blocking this enzyme has been shown to improve cognitive function in some previous studies. The main outcome for the study will be the change in scores on pen and paper tests like the Montreal Cognitive Assessment MoCA.

What will happen during the trial?

The medicine is taken as a tablet and people enrolled in the trial will take either 50mg of the medicine or 50mg of placebo for 12 weeks, with some follow-up checks and testing.

Who can take part in the trial?

People are eligible to take part if they have a diagnosis of dementia with Lewy bodies and have had visual hallucinations in the last month.  At the moment the trial is only open to patients under the care of the hospitals listed below.

How can I get involved?

The trial is taking place at these sites in the UK, of which some are recruiting and some pre-screening. If you or the person you care for is a patient at one of these units, please speak to your consultant.

Dementia Research Unit, Crowborough, East Sussex

Memory Assessment and Research Centre, Moorgreen Hospital, Southampton, Hampshire

Clinical Research Centre (CRC), Dundee

Queen Elizabeth University Hospital, Glasgow

Kings College Hospital, London

West London Mental Health Trust

Greater Manchester Mental Health and Social Care Trust