The symptoms of DLB can be grouped as central, core, suggestive or supportive .
- Fluctuating states of consciousness
Typically people with DLB will experience extreme swings from alertness to confusion. These occur unexpectedly over any period of time, from minutes to days. If a person who has been diagnosed with Alzheimer’s disease can sometimes play cards or follow a game of cricket, it could be DLB instead.
- Visual hallucinations
Two-thirds of patients with DLB experience vivid and recurrent visual hallucinations. For some people these are pleasant visions of animals or small children but others have terrifying, threatening hallucinations, which cause them – and their carers – intense distress.
- Spontaneous Parkinsonism
People with DLB experience motor difficulties seen in PD patients such as slow movement (bradykinesia), rigidity and falls but sometimes do not experience the tremor which is characteristic of PD. With DLB there tends to be greater difficulty in walking, balance and facial impassiveness than in PD [2, 3]. In both diseases the patient may suffer from autonomic symptoms such as sudden drop in blood pressure upon standing, difficulty in swallowing , incontinence or constipation [4, 5].
- Disturbances in REM sleep
REM sleep is the deep sleep in which people dream. A certain amount of good, undisturbed REM sleep is necessary in order for people to function efficiently. DLB sufferers may talk in their sleep or act out their dreams. Some times this is so marked that the sufferer may fall off the bed.
- Severe sensitivity to neuroleptic drugs
Sometimes people with DLB are prescribed neuroleptic (anti-psychotic) drugs to help with their symptoms. This should only be done by someone experienced in the illness as many of these drugs can be extremely harmful or even fatal to people with DLB (see Treatment).
A diagnosis of DLB is less likely if the person has had a stroke or other illness which may have affected motor or mental ability.
- Problems with swallowing or continence
- Other hallucinations ( hearing, smelling or feeling things )
- McKeith I.G., Dickson D., Emre M. et al., Dementia with Lewy Bodies: Diagnosis and Management: Third Report of the DLB Consortium, Neurology 65 (12) (2005), 1863-1872
- McKeith I.G., Mintzer J., Aarsland D., Burn D.,Chiu H., Cohen-Mansfield J., et al, Dementia with Lewy bodies. Lancet Neurol 2004; 3: 19-28
- Mosimann U.P., McKeith I.G., Dementia with Lewy bodies — diagnosis and treatment. Swiss Med Wkly 2003; 133: 131-42
- Knopman D.S., Boeve B.F., Petersen R.C., Essentials of the proper diagnoses of mild cognitive impairment, dementia, and major subtypes of dementia. Mayo Clin Proc 2003; 78: 1290-308
- Burn D.J., McKeith I.G., Current treatment of dementia with Lewy bodies and dementia associated with Parkinson’s disease. Mov Disord 2003; 18 (suppl 6) : 572-9